Metoprolol MCC 25 mg
Presentation:
Tablets containing 25mg metoprolol tartrate, packed in boxes with 3 blisters of 10 tablets each.
Therapeutic action:
Metoprolol is a cardio-selective beta-blocker which acts on b1-receptors principally found in the heart. It reduces the arterial pressure both in clino and ortostatism and also reduces the tendency of increasing pressure after mental and physical effort.
Indications:
- Arterial hypertension
- Angina pectoralis
- Rhythm perturbations (arrhythmia, asystolia)
- Treatment of cardiac failure
- Migraine prevention
Dosage:
Adults: treatment of hypertension on adult patients usually begins with daily doses of 100mg metoprolol tartrate divided in 2 doses. This dose can be raised with 100mg daily after each week of treatment until disered effect is reached. Maximum dose should not surpass 200mg twice daily.
Children: Use of metoprolol tartrate is not recommended on children due to the lack of clinical experience.
Contraindications:
- Hypersensitivity on metoprolol tartrate or to any other of the product excipients
- Bronchial asthma and severe chronical obstructive broncho-pneumopaty
- De-compensated cardiac deficiency
- Cardiac shock
- AV block of 2nd – 3rd degree
- Bradicardy (<45-50 beats/ minute)
- Cardiac insufficiency non responding to treatment
- Severe deficiency of peripheral circulation associated with pain or trophic disturbances
- Hypotension
Precautions:
In angina pectoralis, treatment cannot be abrupt interrupted because rhythm perturbations, myocardial failure or sudden death may appear. Thus, interruption should be made gradually, reducing the doses along 1-2 weeks. When on treatment alcohol should be avoided.
Pregnancy and nursing:
METOPROLOL 25, 50 sau 100 mg – tablets should be used in pregnancy only if it’s drastically needed. Because metoprolol tartrate is excreted in breast milk nursing or metoprolol administration should be interrupted.
Adverse reactions:
Nervous system: fatigue, dizziness, headaches, rarely paresthesia, muscular cramps.
Cardiovascular system: bradicardy, hypotension; rarely cardiac insufficiency, arrhythmia, edema, palpitations, Raynaud syndrome.
Skin: rarely skin eruptions like urticaria, dystrophic lesions and psoriasis like. In rare cases photo sensitivity, excessive transpiration, alopecia.
Respiratory system: occasionally dispnea on effort, bronchial spasm, isolated rhinitis.